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Weakness and numbness in the hands and feet: Vitamin B12 deficiency can cause nerve damage, which can result in numbness or tingling in the hands and feet, as well as muscle weakness

This mechanism would fit into a general concept of how cells are removed from the circulation

Unlike oral supplements, injections bypass the digestive system, ensuring optimal absorption for those with deficiencies or difficulty absorbing B12 from food

N Engl J Med 2021;384(11):989-1002 Wenzel-Seifert K et al

Cell Stem Cell 11 , 615619

Most studies use creatinine to normalize spot urine samples, which is the dehydration product of creatine and creatine phosphate