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Otherslike TB-500are still largely experimental, with real unknowns around safety, dosing, purity, and long-term effects

*Correspondence: Xiaohong Xiang [email protected] This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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During a median follow-up of 15.9 months (range: 12.0-29.7 months), six patients experienced ischaemic recurrences (four patients had one recurrence, one patient had two, and one had three), which represents and incidence rate of 0.04 per person/year

doi: 10.3389/fmolb.2019.00116 42

The escalation schedule provides a framework, not a mandate