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investigated the potential of a photodynamic immunostimulant consisting of a photosensitizer (dihydroporphyrin e6), an ASCT2 inhibitor (V9302), and a PD1/PDL1 blocker (BMS-1) to inhibit glutamine transport and GSH synthesis by targeting glutamine metabolism

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2.4 Application to AD: mapping complexity In AD research, this approach uncovers how phytochemicals modulate core pathological pathways including A aggregation, tau phosphorylation, oxidative stress, and neuroinflammation via shared molecular targets (Naseri et al., 2019)

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This common experience, and the medical professions inability to recognize it, can destroy a patients quality of life, often leading to disability and sometimes even death

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2022;34(3):396-407.e6

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