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Mechanistically, Arctigenin downregulated CPT1-mediated FAO, which further inhibited nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome assemblies in macrophages (Qiao et al., 2020)

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In mice, a high-Se diet increased TCR signaling in CD4 + T cells, increased IL-2 expression, shifted the Th1/Th2 balance toward a Th1 phenotype, higher levels of interferon- (IFN-) and CD40 ligand (60)

Relative risks (RR) and their respective 95% confidence intervals were determined as effect size measures for dichotomous outcomes

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