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The most acceptable theory to explain the departure of the native -synuclein into the fibrillation pathway is the Liquid-Liquid phase separation (Ray et al., 2020)

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For example, arachidonate 5-lipoxygenase (ALOX5) preferentially oxidizes the PUFA arachidonic acid at carbon-5, resulting in the formation of 5- hydroperoxyeicosatetraenoic acid (5-HPETE) (30)

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