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The present trial should also throw light on this

You might wonder how a pill works if you lack intrinsic factor: at very high oral doses, a small amount of B12 can be absorbed directly through the gut wall via passive diffusion, bypassing the need for intrinsic factor entirely [1] [3]

98 In addition, Muc2 gene mutation in mice can induce endoplasmic reticulum stress in intestinal epithelial cells, and the misfolding of intrinsic proteins in the intestinal epithelium triggers the inflammatory response of intestinal epithelial cells, thereby destroying the structure and function of the intestinal barrier in mice and promoting the progression of UC by affecting the intestinal microbiota

I have also had similar symptoms on a couple of occasions and it is normally after a long period without B12 and then a going back on it too quickly

Prioritise Nutrition: Ensure you are consuming enough protein and micronutrients

This is the compound used to protect nerves from damage