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[7] Commonly observed adverse effects include transient injection-site discomfort, breast tenderness, nausea, fluid retention, and mild mood fluctuation, whereas rarer but serious events encompass venous or arterial thromboembolism, gallbladder disease, significant elevation of blood pressure, and hormone-sensitive malignancies such as endometrial or breast cancer

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At these doses, treatment with Fragment 176-191 had no effect on: Vital signs Laboratory parameters ECG results Blood glucose levels IGF-1 levels Tests conducted on research participants taking HGH Fragment 176-191 have been indistinguishable from those conducted on those taking a placebo [1]

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Furthermore, IR and IGF-1R chains can heterodimerize to form a hybrid receptor through which both hormones can signal, although IGF-1 has higher affinity 17,18