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Kemnic TR, Coleman M

From the point of view of the molecules mechanism of action, it is necessary to keep the structure intact at the 17-OH and C-20 keto groups

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To reduce the risk of withdrawal reactions, use a gradual taper to discontinue alprazolam extended-release tablets or reduce the dosage [see Dosage and Administration (2.3), Warnings and Precautions (5.3)]

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3 Compared with standard L-dopa therapy, some researchers recommend the initiation of a COMT inhibitor at the onset of L-dopa therapy to reduce the risk of developing motor complications