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It is understood that released backbone moieties may, for instance, be permanently conjugated to spacer or blocking or linker groups or affinity groups and/or prodrug linker degradation products and that also water-soluble degradation products may comprise degradable bonds

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doi: 10.3389/fphar.2025.1637676 Received 29 May 2025 Accepted 05 September 2025 Published 23 September 2025 Volume 16 - 2025 Edited by Wei Peng, Chengdu University of Traditional Chinese Medicine, China Reviewed by Kaidi Nie, Chengdu University of Traditional Chinese Medicine, China Suresh Kumar, National Institute of Biologicals, India Hao Teng, Guilin Tourism University, China Updates Copyright 2025 Dong, Tang, Qiao, Dong and Cheng