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In AD models, GPX4 levels are reduced compared to wild-type controls (298), and GPX4 overexpression inhibits LPO and protects against A-induced cortical neuron damage (299)

Invest 113, 340345

doi: 10.1080/87559129.2021.1923027 107 MahmoodaniF.GhassemM.BabjiA

Inhibition of -oxidation, mitochondrial dysfunction, and insulin resistance (IR) are the three most important links in these hits as well as targets for carnitine to ameliorate NAFLD