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For example, miR-7-5p inhibits ferroptosis by downregulating mitoferrin and reducing iron levels in radio-resistant cells (Tomita et al., 2019)

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Nevertheless, given the wide range of functions that LECs can potentially perform, they undoubtedly should be considered important stromal component of the TME

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Ferroptosis triggers can be divided into those that act through the cystine/glutamate antiporter system, such as erastin, and those that act by inhibiting the activity of glutathione peroxidase, such as Ras Selective Lethal 3 [73, 74]