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Whiting PH, Kalansooriya A, Holbrook I, Haddad F, Jennings PE

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This process may initiate the inappropriate incorporation of selenocysteine (SeCys) and selenomethionine (SeMet) into proteins, as well as impair their function, which may in turn lead to the development of oxidative stress, i.e., a state in which the oxidizing potential increases to the level that threatens the stability of cellular structures [14]

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However, also dietary/drinking water Se excess is associated with infertility and testicular degeneration in experimental animals, related to higher GPX4 and lactate dehydrogenase activity and higher hydrogen selenide production, and reduced spermatozoa motility, concentration, and typical spermatozoa morphological defects (with the fusion of two midpieces, vacuolization of the cytoplasm, and twisted tails) (85, 105, 117, 169)

GHK-Cu has been extensively studied and demonstrated its potential to '