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Consistent with the clinical observations of hyperprogression in response to nivolumab plus ipilimumab, the preclinical combination of anti-PD-1 plus anti-CTLA-4 (ICT) resulted in significantly increased primary tumor mass (Fig

The -hydroxyl of carnitine is acylated so that acyl-coenzyme A (acyl-CoA), which cannot directly cross the inner mitochondrial membrane, can be transported into the mitochondrial matrix and then participate in -oxidation to produce ATP

Chemical degradation may not be visible but can be detected via HPLC

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Glutamine metabolism and drug resistance Glutamine plays a pivotal role in the progression of tumors, and the strategic limitation of its availability is emerging as a potential therapeutic approach

Our data, however, implies that in cells TPX2 preferentially binds a CEP192-dependent pool of Aurora-A, most likely carrying activation loop phosphorylation