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Additionally, it needs to be considered that PBMC are a heterogenous population with diverse cell types

Oral and topical treatment of painful diabetic polyneuropathy: practice guideline update summary: report of the AAN guideline subcommittee

10.1155/EDR.2003.65 114 SenC

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We will also discuss the potential treatments that may be effective for improving GI symptoms, given the mitochondrial pathophysiology we have highlighted