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When ROS levels exceed those of antioxidant defenses, there is an aberrant increase in free radical generation resulting in mitochondrial damage and leading to oxidative stress and subsequently this increased stress can reduce ETC activity (Gu et al., 2013) (Figure 2)

Nevertheless, the ability to use cysteine proves to be advantageous under carboplatin exposure and allows a faster adaptive response to hypoxia, indicating that cysteine has a role in ovarian cancer cells survival in adverse environments

Brain (2013) 136(Pt 1):14767

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