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Posttreatment, the lesions were not completely absorbed, with the proportions remaining unchanged

10.1038/s42003-021-02883-8 101 LvZ.ShanX.TuQ.WangJ.ChenJ.YangY

Therefore, combination therapy with V-9302 and SLC1A5-specific inhibitors may be a promising therapeutic option for some cancers 97

Int J Mol Med

For example, p53 suppresses the conversion of glucose to glucose-6-phosphate by promoting the decay of HK2 mRNA [26], fructose-6-phosphate to fructose-1,6-bisphosphate by inhibiting PFK1 activity via its target genes, PFKFB3/4 and TIGAR [27,28,29], 3-phosphoglycerate to 2-phosphoglycerate by reducing the protein level of PGAM1 [30], and 2-phosphoglycerate to phosphoenolpyruvate by repressing the expression of ENO3 [31]