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doi: 10.3390/ijms22126493 54 BillesblleCBAzumayaCMKretschRCPowersASGonenSSchneiderSet al

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Cellular stress can lead to overwhelming mitochondrial dysfunction eventually triggering its degradation by mitophagy [45, 46], and mitochondrial fission is necessary for this process [46,47,48,49]

At the apical membrane, carnitine is transported inside the cell via the sodium-coupled carnitine transporter SLC22A5 (OCTN2) (40)

In addition to the gut-brain and gut-kidney axes, the gut microbiota systemically communicates through other axes such as the gut-liver (Albillos et al., 2020), gut-heart (Zhao et al., 2023), gut-skin (Sinha et al., 2021), and gut-bone (Zhang et al., 2024) axes, among others

FeRD, the cellular iron redox imbalance triggered by HMRD plays a detrimental role during the cytokine storm in COVID-19 and its clinical aftermath 27,48,49