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Data availability Additional data are made available in supplementary tables of this manuscript

In a phase 1 study, Voxelotor (Oxbryta/GBT440) binds specifically to the N-terminus of the alpha subunit of HbS to stabilize the oxygenated hemoglobin state (Strader et al., 2019), thus reducing the predisposition to sickling

Loree JM, Strickler JH, Lima Pereira AA, Lam M, Raghav KPS, Morris VK, Menter D, Banks K, Nagy RJ, Raymond V, Overman MJ, Talasaz AA, Lanman RB, Kopetz S

Regular monitoring and adjustment ensure that wellness protocols continue to support optimal outcomes throughout the weight loss journey

10.1016/j.jpeds.2020.10.026 Amanda B Payne, Zunera Gilani, Shana Godfred-Cato, Ermias D Belay, Leora R Feldstein, Manish M Patel, Adrienne G Randolph, Margaret Newhams, Deepam Thomas, Reed Magleby, Katherine Hsu, Meagan Burns, Elizabeth Dufort, Angie Maxted, Michael Pietrowski, Allison Longenberger, Sally Bidol, Justin Henderson, Lynn Sosa, Alexandra Edmundson, Melissa Tobin-DAngelo, Laura Edison, Sabrina Heidemann, Aalok R Singh, John S Giuliano Jr, Lawrence C Kleinman, Keiko M Tarquinio, Rowan F Walsh, Julie C Fitzgerald, Katharine N Clouser, Shira J Gertz, Ryan W Carroll, Christopher L Carroll, Brooke E Hoots, Carrie Reed, F Scott Dahlgren, Matthew E Oster, Timmy J Pierce, Aaron T Curns, Gayle E Langley, Angela P Campbell, MIS-C Incidence Authorship Group

They are often more expensive and are usually part of a hybrid system, not a standalone solution replacing all other technologies