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Because we know that methionine contributes to Wnt/-catenin signaling, its possible that a reduction in methionine may lead to reduced Wnt/-catenin activity

B12 is naturally present in animal-based foods like meat, fish, eggs, and dairy, but it can be deficient in vegans, the elderly, or those with absorption issues (e.g., pernicious anemia)

Libby AF, Starling CR, Josefson FH, Ward SA

20 These three CRPC subtypes manifest distinct responses to Enza: AR +/hi LNCaP-CRPC exhibits an acute and transient sensitivity and AR cyto LAPC4-CRPC and VCaP-CRPC a more drawn-out sensitivity whereas AR -/lo LAPC9-CRPC shows no response to Enza

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In further embodiments, the invention encompasses a method of inhibiting NNMT in vitro or in vivo by contacting a cell expressing NNMT with one or more cations chosen from Tables 1, 2, 3a, and 3b