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Extra-renal CYP27B1 (aka 1-alpha-hydroxylase) is produced in abundance by activated macrophages in granulomas

For sickle cell anemia (D57.x) complications including vaso-occlusive joint pain, our ICD-10 code for knee pain guide covers M25.56x laterality coding for anemia-related joint presentations

Its triple-receptor action distinguishes it from single-receptor agonists

The human evidence is far thinner sometimes nonexistent

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It has also been effective in alleviating joint pain and knee pain by promoting connective tissue healing