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Hypoxia and reoxygenation induce endothelial nitric oxide synthase uncoupling in endothelial cells through tetrahydrobiopterin depletion and S-glutathionylation

These stresses disrupt physiological, biochemical, and metabolic processes, cause oxidative stress, and result in the excessive build-up of reactive oxygen species (ROS), including hydrogen peroxide (H 2 O 2 ), superoxide anion (O 2 - ), hydroxyl radical (OH), and singlet oxygen (O 2 ) (Sachdev et al., 2021

Jeter CR, et al

Okay now if I'm driving a car, and I let go of the steering wheel, and now the car goes and crashes into the wall, is it the car's fault

10.1016/j.ygeno.2022.110274 Genomics

doi: 10.1016/j.molmet.2018.06.004 80 CaoWLiMWuTFengFFengTXuYet al