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doi: 10.1111/j.1743-6109.2011.02354.x 102 Skjldebrand SparreLKollindMCarlstrmK

Dear editor A recent study published in Annals of the Rheumatic Diseases suggests that the expression of hypoxia-inducible factor 1 alpha (HIF1a) in intestinal epithelial cells (IECs) represents a critical check point for the development of arthritis by inhibiting necroptosis of IECs and preserving the intestinal barrier integrity [1]