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Additionally, the mutant huntingtin protein can impair the function of the transcription factor PGC-1, which is crucial for the regulation of antioxidant defenses and mitochondrial biogenesis

After consideration of public comments, we are finalizing, as proposed, to revise 414.1365(d)(3)(i)(A) to state that, except as provided in paragraph (d)(3)(i)(A)( 1 ) of this section, for the CY 2023 through 2024 performance periods/2025 through 2026 MIPS payment years, each selected population health measure that does not have a benchmark or meet the case minimum requirement is excluded from the MVP Participant's total measure achievement points and total available measure achievement points

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