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Mol Brain 4(1):3 Zhang Y-W, Thompson R, Zhang H, Xu H (2011b) APP processing in Alzheimers disease

It was showed in this study that the opioid effects of mitragynine as referenced to the positive control substance, morphine, causing behavioral changed in the rats only at high dose for 1 day treatment or 4 days continuous administration of mitragynine at high and low doses