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Such programs may include mixtures of opioid and nonopioid adjunctive medications, based on evidence from CIPN trials, and also extrapolation from trials in patients with other neuropathic pain syndromes-although such extrapolating must be done with caution, since other syndromes sometimes respond to agents that CIPN does not respond to

Even though the skin is constantly exposed to varying physical, chemical, and microbiological insults, the defense system maintains skin homeostasis by activating a variety of immune cells [1]

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