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In vitro evolution of chemically-modified nucleic acid aptamers: Pros and cons, and comprehensive selection strategies

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In addition, regulatory T cells (Treg cells) and M2 macrophage fractions were significantly higher in poor response group while the fraction of activated NK cells and CD4 cells were substantially higher in disease control group

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Alternative therapy, such as hydroxocobalamin, is advised

Finally, the authors also investigated the pharmacodynamic and pharmacokinetic properties of enolase inhibitor HEX in non-human primates