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Oncogenic activation of the PI3K/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein

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3584-C OUTCOMES OF LIVER TRANSPLANTATION IN PATIENTS WITH ACUTE ALCOHOLIC HEPATITIS BASED ON WAITLIST DURATION Omar Alshuwaykh, California Pacific Medical Center, George Cholankeril, Baylor College of Medicine, Donghee Kim, Stanford University Medical Center and Aijaz Ahmed, Stanford University School of Medicine Background: Acute alcoholic hepatitis is associated with significant short-term mortality and liver transplantation can be a lifesaving option for these patients

According to Maycotte and colleagues, autophagy may precede apoptosis and is necessary for caspase activation, as seen in increased autophagosome formation and LC3 processing when the cells (rat cerebellar granule neurons) were treated with substances that increase ROS, thereby decreasing the cell viability (Maycotte et al., 2010)

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