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Iron levels play a role in CRC progression and can be supplemented through intravenous or oral iron supplementation, with the former being preferred due to fewer gastrointestinal reactions [120, 163]

[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Ansariniya H., Yavari A., Javaheri A., Zare F

This effect is accomplished through the selective inhibition of the anti-apoptotic protein Bcl-2 expression, while significantly upregulating the activity levels of the pro-apoptotic protein Bax and the apoptotic execution factor caspase-9, thereby promoting apoptosis (Safarbalou et al., 2024)

Synergetic effects and inhibition mechanisms of the polysaccharide-selenium nanoparticle complex in human hepatocarcinoma cell proliferation

However, unnecessary supplementation provides no added benefit when levels are already adequate and represents avoidable cost

eGastroenterology 2024;2:e100104