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Description

Direct application of ROS over a relevant time course to tissues at concentrations found in vivo should reproduce damage similar to that observed in the diseased tissue

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ROS and RNS production following IRI damage results from the complex interplay of multiple cellular pathways

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Zileuton, an FDA-approved oral medication for treating asthma, is an ALOX5 inhibitor that exerts neuroprotective effects by blocking ALOX5-mediated glutamate toxicity and ferroptosis in HT22 cells, a mouse hippocampal cell line [301]

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Recent research determined that aryl hydrocarbon receptor (AhR) activation after alcohol intake in the liver, which is mediated by Protein Phosphatase 2 Regulatory Subunit-Bdelta (Ppp2r2d) to promote AMPK dephosphorylation, leading to autophagy inhibition and mitochondrial dysfunction (Kim et al., 2022)

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Cardona, D.C

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Epigenetics 8, 43

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