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doi: 10.1124/dmd.113.053082

Homeostasis of thiol/disulfide in cells is synergistically regulated by the TTase and TRx systems [158]

Lactylation in cardiovascular diseases (CVDs) The involvement of lactylation in the pathogenesis of CVDs, particularly atherosclerosis and myocardial infarction, as well as in conditions such as vascular calcification, neointimal hyperplasia, pulmonary hypertension, heart failure, and radiation-induced heart damage (RIHD), is becoming increasingly elucidated

Whilst we found that melatonin did not affect the concentration of G6P ( Figure 5H ), it did seem to greatly reduce the amount of F6P present in our cell samples, indicating potentially that the key disruption to this pathway occurred at the step where G6P is converted to F6P ( Figure 5E )

In contrast, for CBI caused by other potentially pathogenic microorganisms (PPMs), guidelines advocate a more cautious and individualized approach

Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target