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Neurodegeneration and AD Increased presence and activity of astrocytic Cx43 hemichannels seems to be a common feature of all major neurodegenerative pathologies, including AD, PD, HD, ALS and MS 482,483,484,485,486,487

The molluscs were fed with filtered lake water that had been enriched with nutrients and was given by the same company that provided animals during the experiment (salinity: 3.4% 0.02%, pH: 7.6 0.01, T: 16.77C 0.09C)

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Additionally, SIRT2 modulates the acetylation and activity of key glycolytic enzymes such as LDHA, PKM2, and hexokinase 2 (HK2) in GCs

IRAK4-targeted drugs can potentially block this pathway, reducing cytokine secretion and alleviating HS symptoms