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4.2 Potential impact of gut microbiota on ferroptosis in OA 4.2.1 Gut dysbiosis promotes lipid peroxidation and ferroptosis in OA In patients with OA, the significant dysregulation of the gut microbiota not only manifests as a disorder in the community structure but also profoundly affects the pathological process of OA by precisely regulating the key hub genes in the host lipid metabolism network

Dempsey T, Rosenthal L

The early endosome, generated by the plasma membrane budding inward, is the first stage in the endosomal trafficking route, sorting and determining the fate of the endocytosed cargo (Figure 1) (Woodman and Futter, 2008