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Acute metabolic stress induced by environmental factors (infection and psychosocial stress) known to be associated with schizophrenia can trigger pervasive OxS in neurons [113], leading to mitochondrial dysfunction, which in turn, generates more ROS and neuronal damage

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Intravenous (IV) administration is considered the most effective due to direct absorption into the bloodstream, leading to faster results

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However, because of the multi-target and multi-pathway characteristics of quercetin and its derivatives, it is significant to explore its anti-depression effect and related mechanisms and promote its clinical application