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The reason: since the fragment contains only the C-terminal part, it lacks the binding domains for GHR (most of the affinity of hGH for GHR lies in the central part of the molecule)

10.1016/j.biopha.2019.109730 Biomed Pharmacother

It can be one piece of a texture plan, yet more severe scars often need procedures that create collagen remodeling in the dermis, where the scar begins

(2022) 119:e2200252119

Heat shock proteins at the crossroads of endosomal trafficking pathways

The expression of HIOMT was significantly increased in ulcerative colitis and lymphocytic colitis patients compared with that in healthy subjects (Wu, 2021b)