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Whole body Irradiation (0.05 GY) was found to increase the levels of DC-related cytokines (IL-2, IL-12, and IFN-), promoting biomolecules structural modification [71], triggering anti-tumor immunological responses such as scavenging reactive chemical intermediates, promoting DNA damage repair, reducing inflammation, inducing selective cell apoptosis or senescence, and upregulating both the innate and adaptive arms of the anticancer immune system, allowing the transfer of naive helper T cells to Th1 cells [72,72,73,75]

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Anal Chim Acta 711:716 Thulin P, Nordahl G, Gry M, Yimer G, Aklillu E, Makonnen E, Aderaye G, Lindquist L, Mattsson CM, Ekblom B, Antoine DJ, Park BK, Linder S, Harrill AH, Watkins PB, Glinghammar B, Schuppe-Koistinen I (2014) Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

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Recently, researchers have successfully engineered a dual-mechanism-based nutrient partitioning nanoregulator (DMNPN) that downregulates glutaminase expression and enhances nutrient availability for T cells, thereby bolstering their antitumor immunity [201]