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These include: a) Aldh1a1, Aldh2, Aldh1b1, Cat, Cyp2e1, Adh3a1 and Gclm single knockouts (KO) b) Aldh1a1 and Aldh3a1 knock-in lines (both have mutated the Cys-302 of the active site) c) Aldh1a1/Aldh1b1, Aldh1b1/Aldh2, Cat/Cyp2e1 and Gclm/Nrf2 double knockouts (DKO) d) Conditional Gclc floxed strain e) Hepatocyte-specific Gclc knockout Funded by NIAAA (R24AA022057) Contact Please send inquiries and requests to: Dr

53 Mirvetuximab soravtansine showed limited single-agent activity and likely failed to meet their primary endpoint in phase III trial due to insufficient biomarker stratification

FAPESP (2020/05527-0 R.T.G.)

Oxidative stress concept updated: Definitions, classifications, and regulatory pathways implicated

SSDI is based on the credits from the work that you have done in the last 10 years while SSI is a need based program

Systemic inflammation is believed to be involved in obesity and obesity-induced diabetes type 2, which alters adipose tissue homeostasis