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Histopathological evaluation using H&E staining (Figure 11A) revealed that neurons in the Ischemia-Reperfusion group were disorganized, exhibited contracted and irregular cell bodies, and displayed pyknotic nuclei with indistinct structural features

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[6] After parenteral delivery, cyanocobalamin binds transcobalamin II, permitting receptor mediated endocytosis into virtually all nucleated cells

Elmamoun & Chandran 2018)