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They found that signaling is required before the sheath formation for proper patterning of the spinal column but is not required later in development to maintain structure (Alkhatib et al., 2018)

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At the 12 mg dose level, here is what clinical trials reported: Nausea: 43.2% of participants (versus 10.7% on placebo) Diarrhea: 33.1% of participants (versus 13.4% on placebo) Constipation: 25.0% of participants (versus 8.7% on placebo) Vomiting: 20.9% of participants These percentages tell an important story