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188 Goserelin significantly reduced fibroid growth and endometrial thickness compared with placebos, whereas fulvestrant did not significantly alter fibroid volume or endometrial thickness or change endpoints such as endometrial histology or vaginal bleeding

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More relevantly, using magnetic resonance imaging, Shungu et al

The NOELs identified for respiratory effects were 275 mg/m 3 in rats exposed for 4 weeks and 700 mg/m 3 in hamsters exposed for 13 weeks