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Several natural products have been reported to induce ferroptosis by inhibiting GPX4, such as Capsaicin (27), heteronemin (28) and Eriocitrin (29) ( Figure 3 )

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

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Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate of (styrenemaleic acid copolymer) and (4-amino-6-hydroxypyrazolo[3,4-d]pyrimidine), on hepatic ischemiareperfusion injury

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Future studies are required to delineate the precise molecular mechanisms by which ferroptosis modulates anti-tumor and neuroprotective responses, and to optimize combination therapies for maximal clinical benefit