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In excessive amounts, it leads to intoxication, dehydration, and impaired breathing, raising the risk of blackouts, vomiting, and liver damage

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Small injections of the Piezo1 agonist Yoda1 into the basal forebrain (BF) of mice produced the same pathological manifestations observed after 6 h of sleep deprivation, including long- or short-term fear memory deficits in mice (Ma et al., 2022)

[58] Medical uses [edit] Treatment of deficiency [edit] Severe vitamin B 12 deficiency is initially corrected with daily intramuscular injections of 1000 g of the vitamin, followed by maintenance via monthly injections of the same amount or daily oral dosing of 1000 g

Weight loss itself is generally contraindicated during pregnancy