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B12 itself doesnt make urine orange

Nature 441, 537541

Some individuals may require more frequent injections, while others might benefit from less frequent doses

[DOI] [PubMed] [Google Scholar] 37.Riederer M, Erwa W, Zimmermann R, Frank S, Zechner R

Recent evidence highlights the active and complex roles of BM adipocytes, suggesting that they are not merely passive energy stores but actively regulate multiple functions that can influence hematopoiesis, for instance, either positively or negatively (97)

This hereditary condition impedes the ileum (the final section of the small intestine) from effectively binding and transporting cobalamin into the bloodstream