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doi: 10.1016/j.phymed.2017.09.011 128

A Spanish review published in 1944 reports that hyposecretion of pancreatic enzymes is a common feature of TD (92), and administration of thiamine in children could increase the release of the pancreatic enzymes trypsin, amylase and lipase (93)

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25 DKK-1/3/4 prevent canonical Wnt signalling by binding to LRP5/6 or further forming a tertiary complex with the single transmembrane receptors Kremen 1 and 2, which induce the endocytosis of LRP5/6

Second, the heightened metabolism of L-tryptophan, resulting in decreased tryptophan levels, provides supplementary protective benefits through the inhibition of T-cell growth through the deprivation of immune cells