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In fact, MS was one of the first CNS diseases where gut bacteria were shown to have a causal influence in animal models: in 2011, it was demonstrated that segmented filamentous bacteria in the gut could trigger CNS-autoreactive Th17 cells and provoke an MS-like disease in mice [181]

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2.5.4 Ferroptosisrelated gene signatures Transcriptomic analyses of IPF BALF have identified an eightgene ferroptosis signature (NRAS, EMP1, SLC40A1, MYC, ANGPTL4, PRKCA, MUC1, GABARAPL1) that distinguishes IPF patients from healthy controls and associates with prognosis

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