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The implementation of a small-volume, whole blood stimulation assay for the assessment of vaccine antigen-specific responses that can be set up at the trial site using minimal equipment, followed by sample preservation in RNA stabilisers and storage or transfer to the investigating laboratory for downstream processing, facilitates immunogenicity testing in clinical and field trials

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The observed changes in the inhibitory neurotransmitter system, exemplified by -aminobutyric acid, 212 and the potential for excitotoxicity to alter cognitive levels earlier than A and tau pathologies, 209 suggest that excitotoxicity might hold greater potential in AD treatment

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