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Description

Amplification and expression of the c-myc oncogene in human lung cancer cell lines

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When cells are stimulated by apoptotic signaling, Bcl2-associated X protein (Bax) induces the permeabilization of the outer mitochondrial membrane, activating the initiator Caspase-9 and effector Caspase-3, thereby leading to apoptosis [17, 18]