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Orchestration of H3K27 methylation: mechanisms and therapeutic implication

Thus, we hypothesized that GSH depletion enhances the oxidation of key lipogenic factors, rendering them dysfunctional and targeting them for degradation

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Future research should concentrate on (1) elucidating nAChR roles in genetic PD subtypes (e.g., GBA or SNCA mutation carriers), (2) developing disease-modifying strategies targeting nAChR-ligand interactions beyond symptomatic relief, and (3) integrating multi-omics approaches to identify nAChR-associated biomarkers predictive of therapeutic response

doi: 10.3892/mmr.2014.2563 49