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In the Phase 2 trial, the cohorts that escalated to higher maintenance doses began at 2mg weekly and increased by 2mg every 4 weeks

For instance, the expression of ChR2 in Purkinje cells, which can be induced using transgenic mutant mice, by in utero electroporation or by viral injections [107], allows precise control over action potential firing in their downstream target, the cerebellar nuclei [108] and thereby over cerebellar-evoked excitation or inhibition in the thalamus

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An intrastriatal brain-derived neurotrophic factor infusion restores striatal gene expression in Bdnf heterozygous mice