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Oxidative stress: major executioner in disease pathology, role in sperm DNA damage and preventive strategies

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GCH1, the rate-limiting enzyme in BH4 biosynthesis, catalyzes the first and key regulatory step of this pathway ( 2.1.3.3 FSP1 CoQ10/NADH axis Ferroptosis-suppressor protein 1 (FSP1), coenzyme Q10 (CoQ10), and nicotinamide adenine dinucleotide (NADH) constitute a parallel antioxidant system that functions independently of GPX4 to suppress ferroptosis

They bind to GLP-1 receptors located in the pancreas, brain, and gastrointestinal tract