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doi: 10.1016/j.gene.2018.07.035

Additionally, the endogenous administration of BDNF was shown to protect neurons within the substantia nigra from 6-OHDA and MPTP toxicity, both in rat and primate Parkinson models [31]

Similarly, data in advanced liver disease are sparse

A deep understanding of the pathogenic mechanisms of PD is of crucial importance for overcoming the limitations of current single-target therapies and for developing synergistic treatment strategies capable of simultaneously intervening at multiple key nodes (Fig

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